Εκπαιδευτικό Έργο
Ο Διονύσης Πανδής αποτελεί μέλος της Α’ Νευρολογικής Κλινικής του Πανεπιστημίου Αθηνών και εργάζεται στο Αιγινήτειο Νοσοκομείο με κλινικό και εκπαιδευτικό ρόλο ενώ αποτελεί μέλος των Διοικητικών Συμβουλίων του Πανελληνίου Επιστημονικού Συλλόγου κατά της Επιληψίας και της Ελληνικής Εταιρείας Κλινικής Νευροφυσιολογίας.
Στο πλαίσια αυτά αλλά και προσκεκλημένος και από πολλές άλλες ιατρικές εταιρείες εκπονεί ετησίως πλήθος εκπαιδευτικών διαλέξεων και ομιλιών σε προπτυχιακούς και μεταπτυχιακούς φοιτητές αλλά και σε ιατρούς διαφόρων ειδικοτήτων.
Ιδιαίτερη σημασία δίνει στην εκπαίδευση νέων νευρολόγων στην ηλεκτροεγκεφαλογραφία μέσω των ετήσιων 5 θημερων σχολείων ΗΕΓ, που διοργανώνει με την Ελληνική Εταιρεία Κλινικής Νευροφυσιολογίας στα πρότυπα των διεθνών σχολείων.
Αναζήτηση
Σύγχυση, Νευρολογικά επείγοντα
Προπτυχιακά μαθήματα για φοιτητές νοσηλευτικής:
Νευρολογικά μαθήματα
Μεταπτυχιακό κλινικής νευροφυσιολογίας:
Βασικές αρχές ηλεκτροεγκεφαλογραφίας
Μεταπτυχιακό νευροψυχολογίας:
Νευροψυχολογία της επιληψίας
Μεταπτυχιακό κλινικής και πειραματικής νευροχειρουργικής:
Κλινικό -ΗΕΓ Ετερογένεια των Επιληπτικών κρίσεων
Μεταπτυχιακό καρδιοαναπνευστικής αναζωογόνησης:
Σπασμοί Επιληψίας
Μεταπτυχιακό Νευροεπιστημών:
Introduction to Electroencephalography
1. Epilepsy Curr. 2012 Sep;12(5):184-7. doi: 10.5698/1535-7511-12.5.184.
Seizures in Alzheimer disease: clinical and epidemiological data.
Pandis D, Scarmeas N.
Abstract
Alzheimer disease (AD) and epilepsy are disorders commonly seen in the elderly. Many studies have shown that patients with AD are at increased risk for developing seizures and epilepsy. Whereas, patients with specific types of epilepsy, such as temporal lobe epilepsy (TLE), experience some degree of cognitive dysfunction, questions have been raised as to whether these disorders share some underlying pathophysiologic mechanisms or whether one is an epiphenomenon of the other. In this report, we review some of the available clinical and epidemiologic literature on various aspects of the topic of seizures in AD, including seizure rates and types, risk factors for seizures, electroencephalographic findings, treatment options, limitations, and methodological issues. Overall, multiple aspects of the literature on seizures and epilepsy in AD, including diagnosis, risk factors, the role of EEG in diagnosis, and the response to treatment are not clear and suffer from many methodological limitations and gaps.
2.Epilepsia. 2008 Aug;49(8):1440-5. doi: 10.1111/j.1528-1167.2008.01601.x. Epub 2008 Apr 10.
Seizure remission and relapse in adults with intractable epilepsy: a cohort study.
Choi H, Heiman G, Pandis D, Cantero J, Resor SR, Gilliam FG, Hauser WA.
Abstract
PURPOSE:
To investigate the cumulative probabilities of >or=12 month seizure remission and seizure relapse following remission, and to test the associations of clinical characteristics with these two study end points in a prevalence cohort of intractable adult epilepsy patients during medical management.
METHODS:
A retrospective cohort study of intractable epilepsy patients seen in 2001 at a single center was conducted. Kaplan-Meier analysis was used to estimate the cumulative probabilities of seizure remission and subsequent seizure relapse. Cox proportional hazards models were used to estimate the association (1) between clinical factors and >or=12 month seizure remission and (2) between clinical factors and seizure relapse following remission.
RESULTS:
One hundred eighty-seven subjects met the eligibility criteria for intractable epilepsy. The estimate of probability of remission was about 4% per year. Seizure remission was temporary for some individuals, as 5 out of 20 subjects with remission ultimately relapsed. No clinical factors predicted the likelihood of achieving >or=12 month seizure remission or subsequent seizure relapse.
DISCUSSION:
Some people with intractable epilepsy achieve >or=12 month seizure remission during medical treatment. Remission, however, is only temporary for some individuals. We were unable to identify clear predictors for remission.
3. J Clin Neurosci. 2007 Mar;14(3):229-35.
Chronic inflammatory demyelinating polyneuropathy: a 6-year retrospective clinical study of a hospital-based population.
Rentzos M1, Anyfanti C, Kaponi A, Pandis D, Ioannou M, Vassilopoulos D.
Abstract
We reviewed the clinical, electrophysiological, laboratory and neuroimaging features of 25 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) admitted to Aeginition Hospital from 1996 to 2001. We also investigated the response to several treatment modalities. The aim was to reveal the clinical spectrum of the disease; the diagnostic criteria developed by the Ad Hoc Subcommittee of the American Academy of Neurology (AAN) in 1991 were used. The subjects consisted of 17 men (68%) and eight women (32%) aged 18-81 years (mean age: 48.5 years) with CIDP. Eighteen patients (72%) had a symmetric neuropathy, whereas seven (28%) had an asymmetric neuropathy. Two patients (8%) had a pure sensory neuropathy. Nine (36%) presented with cranial nerve involvement and only one (4%) had central nervous system demyelination. Most patients had a satisfactory response after treatment with corticosteroids, intravenous immunoglobulins, plasma exchange and azathioprine. In conclusion, CIDP is a clinically heterogeneous disorder. It is one of the few serious chronic neuropathies that has a good (although not permanent) treatment response.
4. Eur J Neurol. 2006 Jul;13(7):e5.
Neuromyotonia and myasthenia gravis in the absence of thymoma.
Antelli A, Spengos K, Zambelis T, Pandis D, Tsivgoulis G, Zis V.
Neuromyotonia is a syndrome characterised by motor unit hyperactivity leading to muscle cramps, fasciculations, muscle stiffness, and persistent muscle contraction. In most neuromyotonia patients, the disorder is acquired. An autoimmune or paraneoplastic origin is common.1–3 Myasthenia gravis, thyrotoxicosis, systemic sclerosis, inflammatory demyelinating neuropathies, thymoma, bronchial carcinoma, and small cell lung cancer may be associated. Here, we report a patient with neuromyotonia, associated with myasthenia gravis and anti-voltage-gated potassium channels (VGKC) and anti-acetylcholine receptor (AChR) antibodies without thymoma. A 58 year old man of Portuguese descent presented at our neuromuscular clinic with dysesthesia and hypesthesia in the first three fingers of the right hand. Symptoms had started nine years before and had been attributed to cervical radiculopathy. Over the years, the symptoms had been fluctuating but for the past two months they had become debilitating. Therefore, the patient sought a second opinion. The patient volunteered that, although right hand pain was his main complaint, for many …
5. Archives of Hellenic Medicine 2018, 35(4):481–489
Quality of life of adult patients with epilepsy
Ε. KONSTANDOPOULOU,Μ. LYMPERIDOU, ί. GRAMMATIKOPOULOS, Μ. ROVITHIS, Μ. LINARDAKIS, D. PANDIS, V. RIKOS
OBJECTIVE Investigation of the quality of life (QoL) of adult patients with epilepsy under medical and nursing su- pervision. METHOD Descriptive correlational study of 37 adult patients who had experienced at least one epileptic episode during their lives. The study was conducted in Athens at the Epilepsy Clinic of the First University Neurology Clinic of the “Εginitio” Hospital. The QoL of the patients was evaluated using the Greek version of QOLIE-89. RESULTS The majority of the participants (59.5%) were women, 56.8% had completed secondary education and 46.0% were working at home or were unemployed. The most common type of seizures recorded was simple partial seizures, ex- perienced by 59.5% of the participants. High scores were recorded on all the subscales of the questionnaire, indicat- ing a high level of QoL, and significant positive correlation was observed between the subscales. None of the indi- vidual characteristics of the participants nor items on their medical history was found significantly associated with the overall QoL, as measured by the questionnaire (p>0.05). CONCLUSIONS The level of QoL of the people with epi- lepsy in the present study was found to be high, and not related to their individual characteristics or medical histo- ry. A better understanding by clinicians of the degree of the life satisfaction of patients with epilepsy will lead to the continuous improvement of the treatment provided for these individuals. It is recommended that further studies on QoL and the factors affecting it be carried out with patients with epilepsy.
6. Reliability and validity of a modified amsterdam preoperative anxiety and information scale (Apais)
Vasiliki A. Bakalaki, Ioannis D. Kostakis, Aikaterini Lampadariou, Andreas Kyrozis, Athanasios Chalkias, and Dionysios Pandis
Abstract
RELIABILITY AND VALIDITY OF A MODIFIED AMSTERDAM PREOPERATIVEANXIETY AND INFORMATION SCALE (APAIS)
Vasiliki a. Bakalaki1, ioannis D. kostakis2, aikaterini lampaDariou1, anDreas kyrozis3, athanasios Chalkias4,5 anD Dionysios panDis31∗
Background: Preoperative anxiety is common and can have deleterious effects, such as fluctuations in blood pressure, heart and respiratory rate, resistance to anesthetic induction, higher levels of postoperative pain and poor healing. Our aim was to assess the reliability and validity of the Greek version of the Amsterdam Preoperative Anxiety and Information Scale (APAIS).
Methods: One hundred patients completed a modified (Greek) APAIS questionnaire and the Spielberger’s State-Trait Anxiety Inventory (STAI-State) during routine preoperative screening from March to May 2015. Both general and regional anesthesia patients were included and various clinical data, such as age, sex, level of education, marital status, American Society of Anesthesiologists (ASA) physical status classification system and previous surgery were collected.
Findings: Exploratory factor analysis revealed a new two factors model of the Greek version of APAIS: anxiety and need for information related to anesthesia and anxiety and need for information related to procedure (APAIS-anesthesia: Cronbach’s α =0.844; APAIS-procedure: Cronbach’s α =0.847). We also found a very high correlation between the subscales of APAIS and STAI-State. Furthermore, APAIS discriminated well between sub-groups of patients on the basis of the severity of their procedure.
Conclusions: The Greek version of APAIS with the new structure that emerged can provide anesthesiologists with a reliable and valid instrument to assess easily the preoperative anxiety and the need for information in clinical practice.
7. Epilepsia, 53(Suppl. 5):1–245, 2012 doi: 10.1111/j.1528-1167.2012.03677.p093
ASYMMETRIES OF SLEEP SPINDLES IN HUMAN EPI- LEPSY WITH TEMPORAL OR FRONTOTEMPORAL FOCUS
A. Kyrozis, C. Moschovos, E. Tsoukas, A. Bonakis, D. Pandis, A. Ghika, I. Evdokimidis, and N. Kalfakis
Univ. Athens, Athens, Greece
Purpose: It is unclear whether temporal lobe epileptic foci can affect sleep spindles, which are generated in extratemporal thalamo-cortical cir- cuits. We tested for such effects, the detection of which may have patho- physiologic and clinical diagnostic implications.
Method: Sleep EEG recordings of 6 cryptogenic epilepsy patients with right temporal or frontotemporal focus (TR), 6 with left temporal or frontotemporal focus (TL) and 12 controls with non-epileptic paroxysmal events and normal MRIs were used. Central sleep spindles were detected by a custom-made computer algorithm (MATLAB software). Spectral power, peak frequency, inter-channel transfer function estimate (TFE) angle (reflecting phase difference) and inter-channel coherence were assessed.
Result: No significant inter-hemispheric differences were found for peak frequency and spectral power. Spindles recorded at frontal elec- trodes appeared a few milliseconds earlier on the side of the focus in 11 of 12 epilepsy cases. The lateralization was highly significant (mean€- SEM TFE angles from F3 to F4: TR: + 0.212€0.055; TL: – 0.204€0.077, Tukey test p=0.0057). Coherence was also higher on the side of the epi- leptic focus [Coh (F3Fz)–Coh (F4Fz): TR: -0.055€0.06; TL: +0.09€0.025, Tukey test p=0.028], implying greater synchronization on the side of the focus.
Conclusion: Temporal lobe epilepsy promotes initiation and synchro- nization of sleep spindles on the side of the focus. The observed changes may be the result of network modifications on the side of the focus and/or altered hippocampal-frontal networks that modulate sleep oscillations. The results suggest the possibility of using sleep spindles for the detection of the presence and side of an occult epi- leptic focus.
8. Poster στο 11ο Πανελλήνιο Συνέδριο Επιληψίας, 2017
Η χρησιμότητα του ΗΕΓ μακράς καταγραφής σε ασθενείς με παροδική επιληπτική αμνησία (ΤΕΑ)
Μαρία Στεφανάτου, Διονύσιος Πανδής, Ιωάννης Ευδοκιμίδης
ΣΥΜΠΕΡΑΣΜΑ
Η ΤΕΑ είναι ένα, προσφάτως ταξινομημένο, επιληπτικό σύνδρομο το οποίο τυπικά παραμένει αδιάγνωστο αρχικά. Ο σκοπός μας είναι να υπογραμμίσουμε την αξία του ΗΕΓ μακράς καταγραφής σε ασθενείς με υψηλή κλινική υποψία. Το ΗΕΓ μακράς διάρκειας αποτελεί ένα ασφαλές και ευαίσθητο διαγνωστικό εργαλείο, παρέχοντας τις απαραίτητες πληροφορίες για την καλύτερη διαχείριση των ασθενών.
